Grant: Project Grant

How the new drug, glucagon-like peptide-2, stimulates intestinal growth and function A hormone normally made by the intestines, glucagon-like peptide-2 (GLP2), has recently been approved to treat patients who are have lost large pieces of their intestine due to surgical removal, resulting in their inability to eat food by mouth. We have previously shown that GLP2 requires a complex series of other proteins to stimulate intestinal growth and function. In the proposed studies, we will apply our unique laboratory techniques to animal and cell models in order to fully determine how GLP2 enhances the ability of the intestine to uptake nutrients, permitting patients to eat food normally.