Grant: Operating Grant

Replicating viruses are being investigated as a new class of cancer-targeted therapeutics. These viruses are generally selective for growth in, and destruction of, cancer cells compared with normal healthy cells and tissues. Although early clinical results are promising, there is room for improvement in generating viral therapeutics for specific cancer types which to date remain hard to treat. In this application, we propose studies which will allow us to adapt a promising cancer therapy towards the treatment of pancreatic cancer, for which there are currently limited therapeutic options.