Grant: Operating Grant
University of Calgary
$631,090.00
Stabilization of blood vessels by a genetic pathway downstream of Sonic Hedgehog
FY 2010-11
Summary
Blood vessels are functional at an early stage of development and therefore rapidly need to develop a structure that can withstand the pressures of the circulatory system so that they do not hemorrhage. We use the zebrafish model to identify genes that function in the genetic pathway to stabilize blood vessels. In this work we have identified more than 50 genes that are misregulated in a model of embryonic hemorrhage. We will characterize the functions of three genes in this work, Nkx3.2, FoxF2 and Pim1. We hope to identify genes that would be useful diagnostic markers for human vascular stability defects, or that would be therapeutic targets to improve the outcome after hemorrhage.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
224155
Name
Childs Sarah J
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Developmental Biology
Projecttitle
Stabilization of blood vessels by a genetic pathway downstream of Sonic Hedgehog
Programtype2
Operating Grants
Orgnameinp2
University of Calgary
Cihramount2
$631,090
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Angiogenesis; Development; Hemorrhage; Sonic Hedgehog; Vascular Stabilization
Abstract
Blood vessels are functional at an early stage of development and therefore rapidly need to develop a structure that can withstand the pressures of the circulatory system so that they do not hemorrhage. We use the zebrafish model to identify genes that function in the genetic pathway to stabilize blood vessels. In this work we have identified more than 50 genes that are misregulated in a model of embryonic hemorrhage. We will characterize the functions of three genes in this work, Nkx3.2, FoxF2 and Pim1. We hope to identify genes that would be useful diagnostic markers for human vascular stability defects, or that would be therapeutic targets to improve the outcome after hemorrhage.
Competitiondate
201103
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Childs, Sarah J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $631,090~ $0~
