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Grant: Strategic Projects - Group

University of Guelph

$188,946.00

Genomic selection and association mapping of Atlantic salmon populations

FY 2009-10

Summary
Aquaculture now produces all the Atlantic salmon consumed by Canadians and a significant amount for export. However, disease is a major constraint affecting the sustainability and profitability of this industry. Foremost is disease in marine farmed stock. Disease has a direct impact on farm income through inventory losses and an indirect impact by influencing consumer demand. For example, some consumers are reluctant to buy farmed salmon because they believe they would be supporting an industry which is contributing to disease and parasitism in wild salmon stocks. Fortunately the rate of genetic improvement for functional traits such as disease resistance can be greatly improved by using a new method of animal breeding called genomic selection. This technique uses thousands of "SNP" genetic markers to determine which of the offspring produced by a disease-resistant family have inherited the disease-resistant alleles. Research using dairy bulls at the University of Guelph has shown that this technique increases the response to selection per generation per dollar spent for traits that can only be measured in the relatives of potential breeders. We are proposing to test whether genomic selection can improve growth rate in saltwater, rapid adaptation to seawater, disease resistance and delay sexual maturity relative to a conventional breeding program currently used at Cooke Aquaculture Inc. in New Brunswick. We anticipate that we accomplish this within a three year period using DNA samples and estimated breeding values (EVB) archived over a four year period from past broodstock and their full sib relatives, as well as the performance of their harvested offspring in seawater farm cages. We can then predict genetic changes in economically important traits that would accrue from the use of genomic selection, and compare this to current selection programs. Disease resistance will be determined by challenge of post smolts in the quarantine lab at St. Andrews Biological Station. The ten salmon families challenged will be those whose parents had the highest EVB for growth.
Program
Strategic Projects - Group
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data

As published

Application id
381643-2009
Name nom
Boulding, Elizabeth
Department département
Integrative Biology
Organization id
24
Institution établissement
University of Guelph
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2009
Competition year année de concours
2009
Award amount
188946
Program id
STPGP
Program nane en
Strategic Projects - Group
Program name fr
Projets stratégiques - De groupe
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
1044
Committee name en
Strategic Projects Selection Panel - Food and Bioproducts
Committee name fr
Comité de sélection des projets stratégiques - Aliments et bioproduits
Area of application code
106
Area of application group en
Agriculture and primary food production
Area of application group fr
Agriculture et produits alimentaires primaires
Area of application en
Aquaculture
Area of application fr
Aquiculture
Research subject code
5004
Research subject group en
Genetics
Research subject group fr
Génétique
Research subject en
Genome analysis
Research subject fr
Analyse du génome
Partie
1
Nb partie
3
Application title
Genomic selection and association mapping of Atlantic salmon populations
Keyword
NA
Application summary
Aquaculture now produces all the Atlantic salmon consumed by Canadians and a significant amount for export. However, disease is a major constraint affecting the sustainability and profitability of this industry. Foremost is disease in marine farmed stock. Disease has a direct impact on farm income through inventory losses and an indirect impact by influencing consumer demand. For example, some consumers are reluctant to buy farmed salmon because they believe they would be supporting an industry which is contributing to disease and parasitism in wild salmon stocks. Fortunately the rate of genetic improvement for functional traits such as disease resistance can be greatly improved by using a new method of animal breeding called genomic selection. This technique uses thousands of "SNP" genetic markers to determine which of the offspring produced by a disease-resistant family have inherited the disease-resistant alleles. Research using dairy bulls at the University of Guelph has shown that this technique increases the response to selection per generation per dollar spent for traits that can only be measured in the relatives of potential breeders. We are proposing to test whether genomic selection can improve growth rate in saltwater, rapid adaptation to seawater, disease resistance and delay sexual maturity relative to a conventional breeding program currently used at Cooke Aquaculture Inc. in New Brunswick. We anticipate that we accomplish this within a three year period using DNA samples and estimated breeding values (EVB) archived over a four year period from past broodstock and their full sib relatives, as well as the performance of their harvested offspring in seawater farm cages. We can then predict genetic changes in economically important traits that would accrue from the use of genomic selection, and compare this to current selection programs. Disease resistance will be determined by challenge of post smolts in the quarantine lab at St. Andrews Biological Station. The ten salmon families challenged will be those whose parents had the highest EVB for growth.