Grant: Project Grant
McGill University
$565,731.00
AMPK-dependent regulation of epigenetic modification links physiology to stem cell integrity
FY 2015-16
Summary
Following periods of famine humans manifest a host of disorders that are not always directly related to starvation per se but are thought to result from epigenetic modifications that occur as a result of this stress. The basis behind these modifications is somewhat unclear but they are not associated with mutations in the genome sequence but rather in the manner in which the genes are read and transcribed. These epigenetic changes must somehow be linked to the state of energy of a given organism and we have begun to understand how a single protein called AMPK may play a critical role in a sort of quality control in our germ line stem cells so that future generations who are not subjected to similar conditions will remain reproductive
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
344405
Name
Roy Richard D
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
AMPK-dependent regulation of epigenetic modification links physiology to stem cell integrity
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$565,731
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Ampk; C. Elegans; Chromatin Modification; Dauer; Epigenetics; Germ Line; Histone Methylation; Rnai; Stem Cells; Transgenerational Phenotypes
Abstract
Following periods of famine humans manifest a host of disorders that are not always directly related to starvation per se but are thought to result from epigenetic modifications that occur as a result of this stress. The basis behind these modifications is somewhat unclear but they are not associated with mutations in the genome sequence but rather in the manner in which the genes are read and transcribed. These epigenetic changes must somehow be linked to the state of energy of a given organism and we have begun to understand how a single protein called AMPK may play a critical role in a sort of quality control in our germ line stem cells so that future generations who are not subjected to similar conditions will remain reproductive
Competitiondate
201603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Roy, Richard D
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $565,731~ $0~
