Grant: Project Grant
University of Alberta
$734,400.00
The "Ins" and "Outs" of ventilation during sleep: Brainstem coordination of active inspiration AND expiration
FY 2017-18
Summary
Sleep is a critical period in which breathing is most fragile due to changes in neural network activity that controls breathing. If these respiratory disorders are left untreated, serious cardiometabolic complications arise. We are interested in exploring how manipulation of brainstem structures that control respiratory muscle activity may potentiate ventilation in order to improve breathing in conditions of sleep related respiratory disturbances. With state of the art technology we will demonstrate that potentiation of the neural network that control forced expiration improves breathing stability and increases ventilation and gas exchange.
Department
Program
Project Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
369040
Name
Pagliardini Silvia
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Respiratory System
Projecttitle
The "Ins" and "Outs" of ventilation during sleep: Brainstem coordination of active inspiration AND expiration
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$734,400
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Chemogenetics; Emg Eeg Recordings; Expiration; Optogenetics; Rem Sleep; Respiratory Control; Sleep Disordered Breathing
Abstract
Sleep is a critical period in which breathing is most fragile due to changes in neural network activity that controls breathing. If these respiratory disorders are left untreated, serious cardiometabolic complications arise. We are interested in exploring how manipulation of brainstem structures that control respiratory muscle activity may potentiate ventilation in order to improve breathing in conditions of sleep related respiratory disturbances. With state of the art technology we will demonstrate that potentiation of the neural network that control forced expiration improves breathing stability and increases ventilation and gas exchange.
Competitiondate
201709
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Pagliardini, Silvia
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $734,400~ $0~
