Grant: Operating Grant

The incidence of skin cancer has been increasing rapidly in the past few decades. Although it is well known that ultraviolet light is the primary environmental factor for skin cancers, the exact molecular mechanisms responsible for skin cancer development is still largely unknown. Recently, we have found that the tumour suppressor ING1b plays an important role in genomic stability upon replication stress including ultraviolet radiation. In this proposal, we will investigate the molecular mechanisms of ING1b in recovery of DNA replication and genomic stability. We will also use in vivo animal model to examine if ING1b-deficient mice are predisposed to UV-induced skin cancer development. This project will provide new insights into the molecular mechanisms on ING1 tumour suppressor in genomic stability, which may lead to novel strategies for cancer prevention and treatment.