Grant: Operating Grant

Protein-protein interactions are involved in essentially all biological processes. Furthermore, most diseases are caused by or are associated with aberrant protein-protein interactions. Thus, understanding and manipulating protein-protein interactions holds great potential for enhancing our understanding of how cells work, and also, for developing therapies for devastating diseases such as cancer and infectious disease. This project will develop synthetic antibody libraries as a source of ligands to selectively target proteins inside cells. These antibodies will be invaluable tools for probing cell function and could even be used as therapies for unmet medical needs.