Grant: Project Grant
Université de Montréal
$917,400.00
Regulation of cell communication during collective cell migration
FY 2015-16
Summary
Metastasis is causing over 90% of the mortality associated with solid tumors, new therapeutics against metastasis are thus required to improve the efficiency of current treatments. Studying metastasis formation is challenging, as the process is complicated and involves multiple steps that are hard to reproduce in a laboratory. The migration of the so-called ovarian border cells of the fruit fly Drosophila is an excellent model to study the migration inducing metastasis. Our laboratory has identified mechanisms that regulate the collective behavior of this group of cells, and we recently found a new crucial regulator involved in this process. Here we will elucidate its function and determine to what extent this process is conserved in cancerous cells.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
343826
Name
Emery Gregory
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Regulation of cell communication during collective cell migration
Programtype2
Operating Grants
Orgnameinp2
Université de Montréal
Cihramount2
$917,400
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Actin; Cell Migration; Cytoskeleton; Drosophila; Kinase; Metastasis; Microscopy; Rho Gtpase; Vesicular Trafficking
Abstract
Metastasis is causing over 90% of the mortality associated with solid tumors, new therapeutics against metastasis are thus required to improve the efficiency of current treatments. Studying metastasis formation is challenging, as the process is complicated and involves multiple steps that are hard to reproduce in a laboratory. The migration of the so-called ovarian border cells of the fruit fly Drosophila is an excellent model to study the migration inducing metastasis. Our laboratory has identified mechanisms that regulate the collective behavior of this group of cells, and we recently found a new crucial regulator involved in this process. Here we will elucidate its function and determine to what extent this process is conserved in cancerous cells.
Competitiondate
201603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Emery, Gregory
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $917,400~ $0~
