Grant: Travel Awards - Institute Community Support
Centre hospitalier de l'Université de Montréal (CHUM)
$1,500.00
Retinoic acid improves vitamin A homeostasis, reduces adipocytes hypertrophy and induces beige / brown fat in obese and diabetic ob/ob mice L'Acide Rétinoïque améliore l'homéostasie de la Vitamine A, diminue l'hypertrophie adipocytaire et stimule le gras beige chez les souris obèses et diabétiques ( ob/ob )
FY 2015-16
Summary
Bourses de Voyage ACI
We've demonstrated a Vitamin A derivative (retinoic acid - RA) treatment in diabetic mice, reduces fasting glycaemia,
insulin resistance and body weight (fat), despite iso-caloric food intake, suggesting improved energy metabolism and white
to beige/brown fat convertion. That show therapeutical potential for the RA to be further used for the management of obesity
and type 2 diabetes in humans
Department
Program
Travel Awards - Institute Community Support
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
337299
Name
Manolescu Daniel C
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Institute of Nutrition, Metabolism and Diabetes
Projecttitle
Retinoic acid improves vitamin A homeostasis, reduces adipocytes hypertrophy and induces beige / brown fat in obese and diabetic ob/ob mice L'Acide Rétinoïque améliore l'homéostasie de la Vitamine A, diminue l'hypertrophie adipocytaire et stimule le gras beige chez les souris obèses et diabétiques ( ob/ob )
Programtype2
Undefined
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$1,500
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Beige/Brown Fat; Bourses De Voyage D Aci; Insulin Resistance; Obesity; Pgc1a; Retinoic Acid; Ucp1; Vitamin A Metabolism
Abstract
Bourses de Voyage ACI
We've demonstrated a Vitamin A derivative (retinoic acid - RA) treatment in diabetic mice, reduces fasting glycaemia,
insulin resistance and body weight (fat), despite iso-caloric food intake, suggesting improved energy metabolism and white
to beige/brown fat convertion. That show therapeutical potential for the RA to be further used for the management of obesity
and type 2 diabetes in humans
Competitiondate
201510
Approvedterm2
1 yr 0 mth
Pinamesdelim
Manolescu, Daniel C
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Nutr Metabolism &Diab~ $1,500~ $0~
