Grant: China-Canada Joint Health Research Initiative
Institut de recherches cliniques de Montréal
$150,000.00
Natural killer cells in virus-mediated liver injury
FY 2008-09
Summary
This proposal is aimed at understanding the roles of the SLAM-SAP pathways in immune cell-mediated liver injury during viral infections, as well as in the protection against viral hepatitis. The knowledge gained from these studies will improve our understanding of the mechanisms by which immune cells mediate liver injury and protect against viral infections. In addition, it may help identify new targets for the treatment of immune cell-mediated liver damage and for the protection against viral hepatitis.
The three general aims of this project are to:
1) Examine the expression and function of the SLAM-SAP pathways in liver NK cells.
2) Study the regulation of NK cell-mediated liver injury by the SLAM-SAP pathways.
3) Ascertain the influence of NK cell-mediated protection in a mouse model of viral hepatitis.
Department
Program
China-Canada Joint Health Research Initiative
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
182646
Name
Veillette André
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
National Natural Science Foundation of China (Haidian, Beijing)
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
China-Canada Joint Health Research Initiative - Grants Program
Projecttitle
Natural killer cells in virus-mediated liver injury
Programtype2
Operating Grants
Orgnameinp2
Institut de recherches cliniques de Montréal
Cihramount2
$150,000
Cihrequipment2
$0
Programname2
China-Canada Joint Health Research Initiative
Keyworddelim
Adaptors; Immune System; Liver Infections; Natural Killer Cells; Receptors; Signaling
Abstract
This proposal is aimed at understanding the roles of the SLAM-SAP pathways in immune cell-mediated liver injury during viral infections, as well as in the protection against viral hepatitis. The knowledge gained from these studies will improve our understanding of the mechanisms by which immune cells mediate liver injury and protect against viral infections. In addition, it may help identify new targets for the treatment of immune cell-mediated liver damage and for the protection against viral hepatitis.
The three general aims of this project are to:
1) Examine the expression and function of the SLAM-SAP pathways in liver NK cells.
2) Study the regulation of NK cell-mediated liver injury by the SLAM-SAP pathways.
3) Ascertain the influence of NK cell-mediated protection in a mouse model of viral hepatitis.
Competitiondate
200903
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Veillette, André; Tian, Zhigang
Approvedterm
3 ans 0 mois
Cihrcontribution2
Inst of Nutr Metabolism &Diab~ $150,000~ $0~
