Grant: Project Grant

Scientists have sequenced many human genomes, revealing extensive differences between individuals. Yet, for the most part, we do not know how to use this information about genome variation to predict how it determines cell, organ and body functions. Our group has used a powerful model system, the humble yeast, to address these challenges. We propose to develop new methods, using state-of-the-art cell imaging, to generate a complete picture of how genetic variation influences cell function. This work will lay the foundation for building a high resolution map to guide interpretation of individual genome variation, in the lab and clinic.