Grant: CIHR Fellowship
University of British Columbia
$90,000.00
Mutational drivers of metastatic colorectal cancers
FY 2010-11
Summary
Each human cell contains instructions, called the genome, that direct its growth, function, and death. The genome is made up of 3 billion molecules, called nucleotides. Nucleotides are joined in a specific sequence, but sometimes that sequence becomes mutated and causes cancer and metastasis. Metastasis is the spread of cancer to other parts of the body; it is the main cause of death from cancer. A new technology, called next-generation sequencing, allows researchers to rapidly 'read' the 3 billion nucleotide sequence of a cancer genome. With this technology, we will discover new cancer-specific mutations that drive the progression of noncancerous tissue, to primary tumor tissue, to metastatic tissue. Our aim is to identify genes that when mutated predict or promote metastasis.
Department
Program
CIHR Fellowship
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
214725
Name
Mwenifumbo Jill C
Region
British Columbia
Country
Canada
Orgtype
Research Institution; Institution Paid
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
Mutational drivers of metastatic colorectal cancers
Programtype2
Fellowship Programs
Orgnameinp2
University of British Columbia
Cihramount2
$90,000
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Colorectal Cancer; Copy Number Variation; Genomics; Metastasis; Next-Generation Sequencing; Single Nucleotide Variation
Abstract
Each human cell contains instructions, called the genome, that direct its growth, function, and death. The genome is made up of 3 billion molecules, called nucleotides. Nucleotides are joined in a specific sequence, but sometimes that sequence becomes mutated and causes cancer and metastasis. Metastasis is the spread of cancer to other parts of the body; it is the main cause of death from cancer. A new technology, called next-generation sequencing, allows researchers to rapidly 'read' the 3 billion nucleotide sequence of a cancer genome. With this technology, we will discover new cancer-specific mutations that drive the progression of noncancerous tissue, to primary tumor tissue, to metastatic tissue. Our aim is to identify genes that when mutated predict or promote metastasis.
Competitiondate
201010
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Mwenifumbo, Jill C
Approvedterm
2 ans 0 mois
Cihrcontribution2
~ $90,000~ $0~
