Grant: Operating Grant: COVID-19 - Transmission dynamics/animal host/modeling
McMaster University
$788,000.00
SARS-CoV-2 pathogenesis in human and bat cells and development of in vitro and in vivo infection models
FY 2019-20
Summary
Severe acute respiratory syndrome coronavirus - 2 (SARS-CoV-2) emerged in December 2019 and has infected over 60,000 people, of which over 1800 have died. SARS-CoV-2 shares 96% similarity with a coronavirus found in bats. Bats have been shown to carry a diversity of viruses including coronaviruses globally, without showing signs of disease. Also, major circulating and endemic coronaviruses that are causing disease in humans are speculated to have evolved in bats. Our team's extensive experience in studying coronaviruses in bat and human systems, will allow us to understand interactions of SARS-CoV-2 in bats and humans using a holistic 'One Health' approach. The main objectives of our proposal are to investigate how cell anti-viral responses are induced in human (spillover host) and bat (reservoir host) cells, and to develop animal models to facilitate rapid testing of vaccine candidates and therapeutics.
Department
Program
Operating Grant: COVID-19 - Transmission dynamics/animal host/modeling
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
422740
Name
Mossman Karen L
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Canadian 2019 Novel Coronavirus (2019-nCoV) Rapid Research
Projecttitle
SARS-CoV-2 pathogenesis in human and bat cells and development of in vitro and in vivo infection models
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$788,000
Cihrequipment2
$0
Programname2
Operating Grant: COVID-19 - Transmission dynamics/animal host/modeling
Keyworddelim
Bats; Bioinformatics; Coronavirus; High Throughput Screening; Innate Immunity; Medicinal Chemistry; Novel Therapeutics; Pathogenesis; Virus-Host Interactions
Abstract
Severe acute respiratory syndrome coronavirus - 2 (SARS-CoV-2) emerged in December 2019 and has infected over 60,000 people, of which over 1800 have died. SARS-CoV-2 shares 96% similarity with a coronavirus found in bats. Bats have been shown to carry a diversity of viruses including coronaviruses globally, without showing signs of disease. Also, major circulating and endemic coronaviruses that are causing disease in humans are speculated to have evolved in bats. Our team's extensive experience in studying coronaviruses in bat and human systems, will allow us to understand interactions of SARS-CoV-2 in bats and humans using a holistic 'One Health' approach. The main objectives of our proposal are to investigate how cell anti-viral responses are induced in human (spillover host) and bat (reservoir host) cells, and to develop animal models to facilitate rapid testing of vaccine candidates and therapeutics.
Competitiondate
202002
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Mossman, Karen L
Approvedterm
2 ans 0 mois
Cihrcontribution2
~ $788,000~ $0~
