Grant: Team Grant: CEEHRC - Full application
McGill University
$750,000.00
Role of epigenetic modulation in breast cancer etiology and drug resistance
FY 2012-13
Summary
The major objective of this proposal is to evaluate the contribution of a gene known as EZH2 in breast cancer progression. Using a number of well-defined mouse models we will assess whether elevated expression of EZH2 in breast cancer cells confers resistance to many of the drugs currently used to treat breast cancer. The results of these studies will lead to the development of more effective therapeutic strategies to treat breast cancer patients.
Department
Program
Team Grant: CEEHRC - Full application
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
277365
Name
Muller William J
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Fonds de recherche du Québec - Santé (FRQS)
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Team Grant: Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC)
Projecttitle
Role of epigenetic modulation in breast cancer etiology and drug resistance
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$750,000
Cihrequipment2
$0
Programname2
Team Grant: CEEHRC - Full application
Keyworddelim
Bioinformatics; Biomarkers; Breast Cancer; Chromatin Immunoprecipitation; Drug Resistance; Epigenetics; Functional Genomics; Gene Expression Profiling; Transgenic Mouse Models; Tyrosine Kinase
Abstract
The major objective of this proposal is to evaluate the contribution of a gene known as EZH2 in breast cancer progression. Using a number of well-defined mouse models we will assess whether elevated expression of EZH2 in breast cancer cells confers resistance to many of the drugs currently used to treat breast cancer. The results of these studies will lead to the development of more effective therapeutic strategies to treat breast cancer patients.
Competitiondate
201212
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Muller, William J
Approvedterm
5 ans 0 mois
Cihrcontribution2
Breast Cancer Initiative~ $50,000~ $0~Inst of Cancer Research~ $500,000~ $0~Institute of Genetics~ $200,000~ $0~
