Grant: Operating Grant

Mild traumatic brain injuries (concussions) affect individuals across all ages and sometimes lead to lingering cognitive deficits and mood alterations that prevent affected individuals from resuming the activities of pre-injury life and may increase the risk of developing dementia and neurodegenerative diseases. We propose a longitudinally study of patients after a concussion to identify early neurophysiological markers that might ultimately serve to facilitate diagnosis, gather prognostic insights, test treatment efficacy, and establish objective criteria on which to base return-to-work decisions. We will combine neuroimaging, neurological and neuropsychological measures with neurophysiologic assessements of cortical excitation/inhibition (E/I) balance and plasticity using the real-time integration of transcranial magnetic stimulation (TMS) and electroencephalography (EEG).