Grant: CIHR Fellowship

Gamma-delta T cells protect the body by directly combating bacteria and fungi in barrier tissues, as well as send out signals to initiate an immune response. These T cells serve a critical function as the first line of defense against pathogens; however, they can also contribute to autoimmune diseases and promote cancer progression. The ability of these cells to perform diverse functions is set up during fetal/neonatal life, when these cells develop from blood stem cells. In this proposal, we will define the molecular events that lead to the acquisition of the pro-inflammatory IL-17 programming in gamma-delta T cells. We will focus on the roles of HEB transcription factors that control gene expression, and on the extracellular signals that modulates HEB activity. A better understanding of how these T cells are programmed for function during development will enable us to target and modulate their important immune functions to promote health and combat disease.