Contribution: Industrial Research Assistance Program – Contributions to Firms
48Hour Discovery Inc.
$193,000.00
A New High-Value Service: Establishment of Synthesis and Validation for Drug Discovery
FY 2018-19 · 2018-12-01
Summary
The proposed project will develop a new high-value service client; this involves establishing “synthesis and validation of hits” at 48Hour Discovery INC (48HD). The deliverable from achieving this objective is an extremely valuable investigational new drug (IND) enabling discovery pipeline. The pipeline consists of I) genetically-encoded library technology (BiGEL2) for the discovery of bicyclic ligands for cell-based targets, II) high throughput synthesis of selected discovered ligand, III) measurement of binding and specificity profile and IV) permeability assays. These scaffolds are stable and resilient to simulated gastrointestinal conditions and thus, the discovery platform will provide potentially oral and bioavailable therapeutics.
Department
Program
Industrial Research Assistance Program – Contributions to FirmsIndustrial Research Assistance Program-Contributions to Firms (linked with high confidence)
Recipient
Location
Edmonton|Edmonton, Alberta, Canada
Recipient Type
For-profit organization
Business Number
719831695
Type
Contribution
Source
Proactive Disclosure - Grants and Contributions
Amendments
Each version of the agreement as published, oldest first, with its total as of that version. The amount above is the latest.
| Amendment | Date | Fiscal Year | Total |
|---|---|---|---|
| 1 | 2018-12-01 | 2018-19 | $193,000.00 |
| 2 | 2018-12-01 | 2018-19 | $193,000.00 |
As published
Additional Information
This agreement has been amended 1 time(s). The end date of this agreements has been modified by 32 days.
Additional Information (French)
Cet accord a été modifié 1 fois La date de fin du présent accord a été changé de 32 jours.
Agreement End Date
2020-03-31
Agreement Number
916162
Agreement Start Date
2018-12-01
Agreement Title
A New High-Value Service: Establishment of Synthesis and Validation for Drug Discovery
Agreement Title (French)
Un nouveau service de grande valeur: mise en place d'une synthèse et d'une validation pour la découverte de médicaments
Agreement Type
Contribution
Agreement Value
$193,000.00
Amendment Date
2019-12-02
Amendment Number
2
Coverage
IRAP Contributions to Firms projects stimulate wealth creation for Canada through technological innovation. | Les projets des Contributions aux entreprises stimulent la création de richesse au Canada grâce à l’innovation technologique.
Description
The proposed project will develop a new high-value service client; this involves establishing “synthesis and validation of hits” at 48Hour Discovery INC (48HD). The deliverable from achieving this objective is an extremely valuable investigational new drug (IND) enabling discovery pipeline. The pipeline consists of I) genetically-encoded library technology (BiGEL2) for the discovery of bicyclic ligands for cell-based targets, II) high throughput synthesis of selected discovered ligand, III) measurement of binding and specificity profile and IV) permeability assays. These scaffolds are stable and resilient to simulated gastrointestinal conditions and thus, the discovery platform will provide potentially oral and bioavailable therapeutics.
Description (French)
Le projet proposé développera un nouveau client de service de grande valeur ; cela implique d'établir « la synthèse et la validation des occurrences » à 48Hour Discovery INC (48HD). La réalisation de cet objectif est un nouveau médicament expérimental de recherche (NMR) extrêmement précieux. Le pipeline comprend I) une technologie de bibliothèque génétiquement codée (BiGEL2) pour la découverte de ligands bicycliques pour des cibles à base de cellules, II) la synthèse à haut débit de ligand découvert sélectionné, III) la mesure du profil de liaison et de spécificité et IV) les essais de perméabilité. Ces échafaudages sont stables et résilients aux conditions gastro-intestinales simulées et, par conséquent, la plate-forme de découverte fournira des traitements potentiellement oraux et biodisponibles.
Expected Results
The purpose of IRAP Contributions to Firms is to support research, development, adoption and/or adaptation of innovative or technology-driven new or improved products, services or processes in Canada up to their commercialization
Expected Results (French)
Le PARI, par le biais des Contributions aux entreprises, vise à appuyer la recherche, le développement, l’adaptation et/ou l’adoption au Canada de produits, de services ou de processus novateurs ou axés sur des technologies nouvelles ou améliorées, et ce jusqu’à leur commercialisation
Federal Riding
Edmonton Centre
Federal Riding (French)
Edmonton-Centre
Federal Riding Number
48014
NAICS Code
541710
Organization Code
nrc-cnrc
Organization
National Research Council Canada | Conseil national de recherches Canada
Program Name
Industrial Research Assistance Program – Contributions to Firms
Program Name (French)
Programme d’aide à la recherche industrielle – Contributions aux entreprises
Program Purpose
The purpose of IRAP Contributions to Firms is to support research, development, adoption and/or adaptation of innovative or technology-driven new or improved products, services or processes in Canada up to their commercialization
Program Purpose (French)
Le PARI, par le biais des Contributions aux entreprises, vise à appuyer la recherche, le développement, l’adaptation et/ou l’adoption au Canada de produits, de services ou de processus novateurs ou axés sur des technologies nouvelles ou améliorées, et ce jusqu’à leur commercialisation
Recipient Business Number
719831695
Recipient City
Edmonton|Edmonton
Recipient Country
CA
Recipient Legal Name
48Hour Discovery Inc.
Recipient Postal Code
T5K 0H2
Recipient Province or Territory
AB
Recipient Type
F
Reference Number
172-2018-2019-Q4-916162
