Grant: Project Grant - PA: Breast Cancer Research
University of Alberta
$100,000.00
Role of USP7 and Potential Therapy in Human Cancers.
FY 2023-24
Summary
The importance of tumor suppressor p53 in the prevention of cancer is highlighted by the fact that p53 is inactivated in more than 50% of all human tumors. Regulation of p53 expression and stability is essential for maintaining normal cell growth. p53 is tightly regulated by dynamic ubiquitination and deubiquitination. Deubiquitination has emerged as an important mechanism of p53 regulation. The research team of Dr. Leng is particularly interested in three molecules called USP7, UBE4B, and p53, which appear to regulate the growth of tumors. They propose to study the mechanism of the roles and regulation of the UBE4B-p53 axis by USP7 in tumors. They are using cutting-edge molecular tools to study the mechanisms of how these molecules regulate p53. Thus, the outcome of this proposal has significant implications and a possible effect on cancer therapy.
Department
Program
Project Grant - PA: Breast Cancer Research
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
494924
Name
Leng Roger P
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Progression & Therapeutics 2
Projecttitle
Role of USP7 and Potential Therapy in Human Cancers.
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Project Grant - PA: Breast Cancer Research
Keyworddelim
Breast Cancer; Deubiquitination; Oncogene; P53; Protein Stability; Ube4b; Ubiquitination; Usp7
Abstract
The importance of tumor suppressor p53 in the prevention of cancer is highlighted by the fact that p53 is inactivated in more than 50% of all human tumors. Regulation of p53 expression and stability is essential for maintaining normal cell growth. p53 is tightly regulated by dynamic ubiquitination and deubiquitination. Deubiquitination has emerged as an important mechanism of p53 regulation. The research team of Dr. Leng is particularly interested in three molecules called USP7, UBE4B, and p53, which appear to regulate the growth of tumors. They propose to study the mechanism of the roles and regulation of the UBE4B-p53 axis by USP7 in tumors. They are using cutting-edge molecular tools to study the mechanisms of how these molecules regulate p53. Thus, the outcome of this proposal has significant implications and a possible effect on cancer therapy.
Competitiondate
202309
Approvedterm2
1 yr 0 mth
Pinamesdelim
Leng, Roger P
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
