Grant: Team Grant: Health Challenges in Chronic Inflammation Initiative - (Full Appl)

Imagine if you could look inside the lung and see what happens early that leads to chronic diseases like Cancer, Infections or Environmental Diseases like Farmers Lung or Asbestosis or Silicosis. We finally can using a new type of microscope and a new imaging approach. We can look at all different immune cells and determine why they do not eradicate tumor cells and fungi or why they do get very angry when a foreign particle of silica (the most important cause of fibrotic lung disease) enters the lung. A new deadly pathogen has moved to Canada due to global warming and is spreading with no known cure. It enters lungs and then goes to brain. Our new imaging will find its weakness and test new drugs to kill it and cancers and prevent environmental lung disease.