Grant: Discovery Grants Program - Individual
Lakehead University
$30,000.00
Molecular variants of human papillomavirus: impact on viral life cycle and persistence
FY 2010-11
Summary
Human papillomavirus (HPV) is a DNA virus that infects coating tissues of the body such as skin. More than 200 types have been identified and a subset of these HPVs can ""transform"" healthy tissue from a benign to a malignant state. This occurs only in approximately one of a hundred infected individuals and is related to the ability of HPV to persist in the host. In particular one HPV of the transforming types is more prone to persist than other types, which may be caused by ""variants"" in its DNA genome. This HPV is also most prevalent worldwide. By analyzing the activities of variants of this specific type during the viral life cycle we will comprehend the role viral variants play in persistence. This proposal addresses a basic, central theme of virus biology. The concept that viral variants drive evolution by impacting on viral drift and shift to ensure viral progeny has not been tested previously and will potentially lead to new discoveries.
Program
Discovery Grants Program - Individual
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
355858-2008
Name nom
Zehbe, Ingeborg
Department département
Biology
Organization id
25
Institution établissement
Lakehead University
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2010
Competition year année de concours
2008
Award amount
30000
Program id
RGPIN
Program name en
Discovery Grants Program - Individual
Program name fr
Programme de subventions à la découverte - individuelles
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
32
Committee name en
Cell Biology
Committee name fr
Biologie cellulaire
Area of application code
1201
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Life sciences (including biotechnology)
Area of application fr
Sciences de la vie (y compris biotechnologie)
Research subject code
5200
Research subject group en
Microbiology
Research subject group fr
Microbiologie
Research subject en
Microbiology
Research subject fr
Microbiologie
Partie
3
Nb partie
5
Application title
Molecular variants of human papillomavirus: impact on viral life cycle and persistence
Keyword
NSERC
Application summary
Human papillomavirus (HPV) is a DNA virus that infects coating tissues of the body such as skin. More than 200 types have been identified and a subset of these HPVs can ""transform"" healthy tissue from a benign to a malignant state. This occurs only in approximately one of a hundred infected individuals and is related to the ability of HPV to persist in the host. In particular one HPV of the transforming types is more prone to persist than other types, which may be caused by ""variants"" in its DNA genome. This HPV is also most prevalent worldwide. By analyzing the activities of variants of this specific type during the viral life cycle we will comprehend the role viral variants play in persistence. This proposal addresses a basic, central theme of virus biology. The concept that viral variants drive evolution by impacting on viral drift and shift to ensure viral progeny has not been tested previously and will potentially lead to new discoveries.
