Grant: Collaborative Research and Development Grants
University of Manitoba
$61,126.00
Lipid matrix microencapsulation for effective delivery of essential oils to improve gut health in pigs
FY 2018-19
Summary
Piglets are highly susceptible to various stressors, including bacterial diseases, resulting in compromised growth performance and high mortality. Antibiotics have long been used at sub-therapeutic levels in pig diets especially in nursery diets to control incidences of post-weaning diarrhea and to maintain growth performance. However, the current trend in the swine industry world-wide is to minimize or eliminate the use of in-feed antibiotics due to increased public concerns over the spread of antibiotic resistance in zoonotic bacterial pathogens, which poses a threat to public health. As a result, there has been significantly increased interest to develop alternatives to antibiotics with similar antimicrobial and growth-promoting effects without inducing bacterial resistance and potential side effects to pigs. Essential oils represent one of the most promising alternatives to antibiotics. However, their application in pig production has been limited, largely owing to lack of full understanding the modes of action and effective delivery methods. Our research team proposes to first develop an effective delivery method with lipid matrix microencapsulation to allow slow release of compounds in the gut. Then we will functionally assess the potential effect of encapsulated essential oils and organic acids for controlling enteric bacterial pathogens and improving nutrient absorption and barrier function in weaned pigs challenged with Escherichia coli K88+. In this project, we will develop and optimize a proper microencapsulation technology that can effectively deliver essential oils for improving gut health. These findings will help our partners to not only improve exiting technology, but also lead to new product development. This research will contribute greatly to the sustainability and competitiveness of both Manitoba and Canadian pork industries by developing innovative strategies for enhancing gut health and feed efficiency, along with the healthfulness of pork products.
Program
Collaborative Research and Development Grants
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
503580-2016
Name nom
Yang, Chengbo
Department département
Animal Science
Organization id
19
Institution établissement
University of Manitoba
Province en
Manitoba
Province fr
Manitoba
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2018
Competition year année de concours
2016
Award amount
61126
Program id
CRDPJ
Program name en
Collaborative Research and Development Grants
Program name fr
Subventions de recherche et développement coopérative
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
96
Committee name en
RPP Internal Decision Cttee
Committee name fr
Cté de décision interne - PPR
Area of application code
101
Area of application group en
Agriculture and primary food production
Area of application group fr
Agriculture et produits alimentaires primaires
Area of application en
Animal production and animal primary products
Area of application fr
Production animale et produits animaux primaires
Research subject code
5511
Research subject group en
Animal biology
Research subject group fr
Biologie animale
Research subject en
Animal nutrition and husbandry
Research subject fr
Nutrition et élevage des animaux
Partie
2
Nb partie
2
Application title
Lipid matrix microencapsulation for effective delivery of essential oils to improve gut health in pigs
Keyword
NSERC
Application summary
Piglets are highly susceptible to various stressors, including bacterial diseases, resulting in compromised growth performance and high mortality. Antibiotics have long been used at sub-therapeutic levels in pig diets especially in nursery diets to control incidences of post-weaning diarrhea and to maintain growth performance. However, the current trend in the swine industry world-wide is to minimize or eliminate the use of in-feed antibiotics due to increased public concerns over the spread of antibiotic resistance in zoonotic bacterial pathogens, which poses a threat to public health. As a result, there has been significantly increased interest to develop alternatives to antibiotics with similar antimicrobial and growth-promoting effects without inducing bacterial resistance and potential side effects to pigs. Essential oils represent one of the most promising alternatives to antibiotics. However, their application in pig production has been limited, largely owing to lack of full understanding the modes of action and effective delivery methods. Our research team proposes to first develop an effective delivery method with lipid matrix microencapsulation to allow slow release of compounds in the gut. Then we will functionally assess the potential effect of encapsulated essential oils and organic acids for controlling enteric bacterial pathogens and improving nutrient absorption and barrier function in weaned pigs challenged with Escherichia coli K88+. In this project, we will develop and optimize a proper microencapsulation technology that can effectively deliver essential oils for improving gut health. These findings will help our partners to not only improve exiting technology, but also lead to new product development. This research will contribute greatly to the sustainability and competitiveness of both Manitoba and Canadian pork industries by developing innovative strategies for enhancing gut health and feed efficiency, along with the healthfulness of pork products.
