Grant: Project Grant
McGill University
$994,500.00
Molecular regulation of satellite cell-mediated muscle repair
FY 2025-26
Summary
Muscle stem cells are adult stem cells residing in the muscle tissue that have the ability to repair damaged muscle, a process known as muscle regeneration. Our goal is to identify the molecular signals that control muscle stem cells during healthy muscle regeneration. By understanding healthy muscle regeneration, we can apply this knowledge to determine the cause of impaired regeneration in muscle degenerative diseases. Duchenne muscular dystrophy (DMD) is a lethal muscle degenerative disease affecting one in every 5,000 boys in Canada. While corticosteroid treatment can delay disease progression, there is still no effective cure for DMD. Our research aims to devise strategies that target muscle stem cells and enhance their ability to repair muscle as a therapeutic strategy for DMD.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
532600
Name
Chang Natasha C
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Movement & Exercise
Projecttitle
Molecular regulation of satellite cell-mediated muscle repair
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$994,500
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Differentiation; Duchenne Muscular Dystrophy; Muscle Degeneration; Muscle Regeneration; Muscle Repair; Muscle Stem Cells; Myogenesis; Phosphatase; Ptpn1; Skeletal Muscle
Abstract
Muscle stem cells are adult stem cells residing in the muscle tissue that have the ability to repair damaged muscle, a process known as muscle regeneration. Our goal is to identify the molecular signals that control muscle stem cells during healthy muscle regeneration. By understanding healthy muscle regeneration, we can apply this knowledge to determine the cause of impaired regeneration in muscle degenerative diseases. Duchenne muscular dystrophy (DMD) is a lethal muscle degenerative disease affecting one in every 5,000 boys in Canada. While corticosteroid treatment can delay disease progression, there is still no effective cure for DMD. Our research aims to devise strategies that target muscle stem cells and enhance their ability to repair muscle as a therapeutic strategy for DMD.
Competitiondate
202509
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Chang, Natasha C
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $994,500~ $0~
