Grant: Discovery Grants Program - Individual

Cells contain proteins in their membranes that enable the transfer of important nutrients into the cell, as well as the removal of unwanted substances from the cells. We are studying one particular type of these ""transport"" proteins that is involved in the cellular uptake and release of nucleosides. Nucleosides are a class of substances that are used as the building blocks for DNA and RNA, and are also important for controlling many other aspects of cell function. Cells require different levels of nucleosides at different times, and must adapt to their environment to ensure that the nucleoside concentrations, both inside and outside the cell, are maintained at specific levels. We are studying this cellular adaptation process. Our studies are focussed on how cells regulate the number and activity of ""nucleoside transporters"". An increase or decrease in nucleoside transporter activity has been known to modify blood flow to tissues, protect the heart and brain tissue from damage during transient ischemic episodes, and modify the duration of seizures. A better understanding of how the body regulates these transporters will enhance our ability to develop better therapies for conditions such as heart failure, seizures, and stroke. These studies will also enhance our understanding of how the cell regulates its metabolism in response to environmental influences.