Grant: Operating Grant
McMaster University
$765,360.00
Role of NK cells in innate defense against mucosal viral infections
FY 2011-12
Summary
Herpes simplex virus type 2 (HSV-2) is a virus and causes the most common sexually transmitted infection (STI) worldwide with over 1 billion infected individuals. In Canada and the US, nearly 55 million people carry HSV-2 and up to 4 million of them suffer from frequent recurrent outbreaks of genital herpes. In addition, genital herpes is a risk factor for other STIs, such as HIV-1. Currently there is no effective vaccine or treatment against HSV-2. A better understanding of the host defense against HSV-2 is required for an efficient control of this ubiquitous pathogen. Here we propose experiments to understand our innate defense against herpes at the genital tract.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
253595
Name
Ashkar Ali A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Role of NK cells in innate defense against mucosal viral infections
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$765,360
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Animal Models; Antiviral Immunity; Hsv-2; Innate Immunity; Nk Cells; Type I Infs; Viral Infections
Abstract
Herpes simplex virus type 2 (HSV-2) is a virus and causes the most common sexually transmitted infection (STI) worldwide with over 1 billion infected individuals. In Canada and the US, nearly 55 million people carry HSV-2 and up to 4 million of them suffer from frequent recurrent outbreaks of genital herpes. In addition, genital herpes is a risk factor for other STIs, such as HIV-1. Currently there is no effective vaccine or treatment against HSV-2. A better understanding of the host defense against HSV-2 is required for an efficient control of this ubiquitous pathogen. Here we propose experiments to understand our innate defense against herpes at the genital tract.
Competitiondate
201203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Ashkar, Ali A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $765,360~ $0~
