Grant: Project Grant
University of Calgary
$696,150.00
A bioprocess that optimizes safe Human iPSCs for the treatment of osteoporotic fractures
FY 2021-22
Summary
Throughout the lifespan, bone remodels in response to damage, such as fracture. However, diseases such as osteoporosis can cause impaired bone healing, increasing the risk of progression to non-repairing defects called fracture non-unions. Promoting the healing of fracture non-unions is a promising target for bone tissue engineering due to the limited success of current clinical treatment methods in patients with poor bone quality. However,
there are still two main roadblocks in translating pluripotent stem cell (PSC) therapies into the clinic are: 1.) Incomplete differentiation leading to tumor formation and 2.) Clinically insufficient cell numbers. Our team has formulated a solution to both of these problems and will apply our safe PSC therapy to osteoporotic fracture repair, which is a global health concern with 1 in 4 Canadians suffering from an osteoporotic fracture in their lifetime. The outcomes of this study provide fundamental knowledge required for developing safe and effective stem cell therapies to treat bone fractures in patients with osteoporosis.
Department
Program
Project Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
451329
Name
Krawetz Roman J
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage
Projecttitle
A bioprocess that optimizes safe Human iPSCs for the treatment of osteoporotic fractures
Programtype2
Operating Grants
Orgnameinp2
University of Calgary
Cihramount2
$696,150
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Biomaterials; In Vivo Imaging; Induced Pluripotent Stem Cells; Osteoblasts; Osteoporosis; Regenerative Medicine; Repair And Regeneration; Tissue Engineering; Tissue Preservation; Xenograft
Abstract
Throughout the lifespan, bone remodels in response to damage, such as fracture. However, diseases such as osteoporosis can cause impaired bone healing, increasing the risk of progression to non-repairing defects called fracture non-unions. Promoting the healing of fracture non-unions is a promising target for bone tissue engineering due to the limited success of current clinical treatment methods in patients with poor bone quality. However,
there are still two main roadblocks in translating pluripotent stem cell (PSC) therapies into the clinic are: 1.) Incomplete differentiation leading to tumor formation and 2.) Clinically insufficient cell numbers. Our team has formulated a solution to both of these problems and will apply our safe PSC therapy to osteoporotic fracture repair, which is a global health concern with 1 in 4 Canadians suffering from an osteoporotic fracture in their lifetime. The outcomes of this study provide fundamental knowledge required for developing safe and effective stem cell therapies to treat bone fractures in patients with osteoporosis.
Competitiondate
202109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Krawetz, Roman J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $696,150~ $0~
