Grant: Travel Awards - Institute Community Support
University of British Columbia
$1,000.00
Genetic variation in the cholesteryl ester transfer protein (CETP) gene influences HDL cholesterol levels and clinical outcomes in sepsis
FY 2017-18
Summary
Sepsis is one of the leading causes of death of Canadians. Sepsis occurs when the immune system is activated by microbes during a severe infection. "Good" cholesterol known as high-density lipoprotein can act like a mop to clean up the toxins produced by these microbes. Good cholesterol levels are known to drop acutely during sepsis, and we have recently shown that the degree of drop is a very strong predictor of whether or not a patient will survive sepsis. Lower levels of good cholesterol predict worse outcomes.
How and why HDL levels drop during sepsis is unknown. The major goal of this project was to investigate genetic mechanisms that determine good cholesterol levels during sepsis. We discovered a gene called CETP that plays an important role in determining good cholesterol levels during sepsis, and thereby contributing to whether a patient will survive sepsis. The results of this research could lead to new ways to treat sepsis, for example by altering the function of CETP, or to predict a patient's outcome in sepsis by determining his or her CETP genetics.
Department
Program
Travel Awards - Institute Community Support
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
382824
Name
Trinder Mark E
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Clinical
Prcname2
ICRH - International Symposium on Atherosclerosis (ISA) Travel Awards
Projecttitle
Genetic variation in the cholesteryl ester transfer protein (CETP) gene influences HDL cholesterol levels and clinical outcomes in sepsis
Programtype2
Undefined
Orgnameinp2
University of British Columbia
Cihramount2
$1,000
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Cholesterol; Cholesteryl Ester Transfer Protein; Genetics; High-Density Lipoprotein; Lipids; Lipoprotein; Metabolism; Next-Generation Sequencing; Sepsis
Abstract
Sepsis is one of the leading causes of death of Canadians. Sepsis occurs when the immune system is activated by microbes during a severe infection. "Good" cholesterol known as high-density lipoprotein can act like a mop to clean up the toxins produced by these microbes. Good cholesterol levels are known to drop acutely during sepsis, and we have recently shown that the degree of drop is a very strong predictor of whether or not a patient will survive sepsis. Lower levels of good cholesterol predict worse outcomes.
How and why HDL levels drop during sepsis is unknown. The major goal of this project was to investigate genetic mechanisms that determine good cholesterol levels during sepsis. We discovered a gene called CETP that plays an important role in determining good cholesterol levels during sepsis, and thereby contributing to whether a patient will survive sepsis. The results of this research could lead to new ways to treat sepsis, for example by altering the function of CETP, or to predict a patient's outcome in sepsis by determining his or her CETP genetics.
Competitiondate
201802
Approvedterm2
1 yr 0 mth
Pinamesdelim
Trinder, Mark E
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Circ &Respiratory Hlth~ $1,000~ $0~
