Grant: Project Grant
Unity Health Toronto
$765,000.00
BRCA1 therapy for heart failure
FY 2016-17
Summary
Heart failure (HF) occurs when the heart is damaged and unable to pump blood normally
resulting in reduced oxygen and nutrient supply to the rest of the body. It is typically caused by a progressive increase in dying or dead heart cells resulting in loss of heart muscle function. We previously showed that the breast cancer gene BRCA1 has an important role in maintaining heart cell survival. In this study, we will examine in various established HF models the therapeutic potential of directed BRCA1 gene delivery to the heart to reduce and/or slow down heart cell death thereby improving heart muscle function and increasing overall survival.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
354693
Name
Verma Subodh S
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
BRCA1 therapy for heart failure
Programtype2
Operating Grants
Orgnameinp2
Unity Health Toronto
Cihramount2
$765,000
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Brca1; Gene Delivery (Aav9-Brca1); Heart Failure; Murine Genotoxic Stress Model; Murine Hypertrophy Model,; Murine Myocardial Infarction Model; Porcine Myocardial Infarction Model
Abstract
Heart failure (HF) occurs when the heart is damaged and unable to pump blood normally
resulting in reduced oxygen and nutrient supply to the rest of the body. It is typically caused by a progressive increase in dying or dead heart cells resulting in loss of heart muscle function. We previously showed that the breast cancer gene BRCA1 has an important role in maintaining heart cell survival. In this study, we will examine in various established HF models the therapeutic potential of directed BRCA1 gene delivery to the heart to reduce and/or slow down heart cell death thereby improving heart muscle function and increasing overall survival.
Competitiondate
201610
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Verma, Subodh S; Fedak, Paul William M; Singh, Krishna K
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $765,000~ $0~
