Grant: Operating Grant
University of Calgary
$601,280.00
The relationship between proteases, protease activated receptors and cytokines in mediating osteoarthritis pain
FY 2010-11
Summary
Osteoarthritis (OA) is the most common form of arthritis affecting 1 in 10 Canadians. The number one concern for OA sufferers is the alleviation of joint pain; however, current analgesics are either ineffective or produce toxic side-effects. Thus, there is a pressing need to discover novel drug targets to manage OA pain. During OA, enzymes are released into the joint which cause destruction of joint tissues. In addition to their digesting effects, these enzymes can also signal pain by acting on a unique group of receptors called PARs. This proposal will examine how these enzymes activate PARs in diseased joints to cause pain and disability. This work will improve our understanding of joint neurobiology and has the potential to uncover new approaches to effectively relieve OA pain.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
210161
Name
McDougall Jason J
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage
Projecttitle
The relationship between proteases, protease activated receptors and cytokines in mediating osteoarthritis pain
Programtype2
Operating Grants
Orgnameinp2
University of Calgary
Cihramount2
$601,280
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Animal Models; Cytokines; Electrophysiology; Osteoarthritis; Pain; Protease Activated Receptors
Abstract
Osteoarthritis (OA) is the most common form of arthritis affecting 1 in 10 Canadians. The number one concern for OA sufferers is the alleviation of joint pain; however, current analgesics are either ineffective or produce toxic side-effects. Thus, there is a pressing need to discover novel drug targets to manage OA pain. During OA, enzymes are released into the joint which cause destruction of joint tissues. In addition to their digesting effects, these enzymes can also signal pain by acting on a unique group of receptors called PARs. This proposal will examine how these enzymes activate PARs in diseased joints to cause pain and disability. This work will improve our understanding of joint neurobiology and has the potential to uncover new approaches to effectively relieve OA pain.
Competitiondate
201009
Approvedterm2
5 yrs 0 mth
Pinamesdelim
McDougall, Jason J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $601,280~ $0~
