Grant: Travel Awards - Institute Community Support
University of British Columbia
$1,000.00
Synthesis and Evaluation of 18F-AmBF3-PSMA Derivatives as PET Imaging Agents for Prostate Cancer
FY 2015-16
Summary
Prostate specific membrane antigen (PSMA) is an abundant protein on the surface of prostate cancer cells. Therefore, PSMA is a promising target for specific imaging of prostate cancer and may serve as a target for therapeutic applications. Currently, a few PSMA-targeting imaging agents have been introduced in clinical studies for imaging prostate cancer by positron emission tomography/computer tomography (PET/CT). 18F-DCFPyL is currently the most sensitive PSMA-targeting agent for imaging prostate cancer by PET/CT. However, the procedure for producing 18F-DCFPyL involves multiple synthetic steps, and is therefore not readily available. Herein, two easily synthesized PSMA-targeting imaging agents were generated and evaluated for prostate cancer imaging. Both PSMA-targeting imaging agents showed excellent tumor targeting characteristics in live mice and allowed for clear visualization of the prostatic cancer tumors. The data suggests that the new imaging agents are promising for detecting PSMA-abundant prostate cancers and may provide valuable diagnostic information.
Department
Program
Travel Awards - Institute Community Support
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
346938
Name
Kuo Hsiou-Ting
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Institute of Cancer Research
Projecttitle
Synthesis and Evaluation of 18F-AmBF3-PSMA Derivatives as PET Imaging Agents for Prostate Cancer
Programtype2
Undefined
Orgnameinp2
University of British Columbia
Cihramount2
$1,000
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Diagnostics; Molecular Imaging; Positron Emission Tomography; Prostate Cancer; Psma
Abstract
Prostate specific membrane antigen (PSMA) is an abundant protein on the surface of prostate cancer cells. Therefore, PSMA is a promising target for specific imaging of prostate cancer and may serve as a target for therapeutic applications. Currently, a few PSMA-targeting imaging agents have been introduced in clinical studies for imaging prostate cancer by positron emission tomography/computer tomography (PET/CT). 18F-DCFPyL is currently the most sensitive PSMA-targeting agent for imaging prostate cancer by PET/CT. However, the procedure for producing 18F-DCFPyL involves multiple synthetic steps, and is therefore not readily available. Herein, two easily synthesized PSMA-targeting imaging agents were generated and evaluated for prostate cancer imaging. Both PSMA-targeting imaging agents showed excellent tumor targeting characteristics in live mice and allowed for clear visualization of the prostatic cancer tumors. The data suggests that the new imaging agents are promising for detecting PSMA-abundant prostate cancers and may provide valuable diagnostic information.
Competitiondate
201601
Approvedterm2
1 yr 0 mth
Pinamesdelim
Kuo, Hsiou-Ting
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Cancer Research~ $1,000~ $0~
