Grant: Team Grant: Health Challenges in Chronic Inflammation Initiative - (Full Appl)
University of Toronto
$2,441,137.00
Nod-like receptors: linking innate immunity and inflammation to chronic disease
FY 2013-14
Summary
The Nod-like receptors (NLRs) are a family of genes that control the body's response to infection and injury. Since these genes control inflammation pathways in the body, if they are activated inappropriately, they can cause the development of a number of chronic diseases, including inflammatory bowel disease, cardiovascular and chronic kidney disease. Inappropriate NLR activation can also predispose people to chronic bacterial infections. Our team believes that the NLRs are important genes in inflammation and chronic disease and that efforts should be made to understand how they work and transfer that knowledge to help patients with common chronic conditions that involve the gut, heart and kidneys. Our goal with this project is to identify key pathways that are triggered by NLRs that control infection, inflammation, healing or chronic tissue damage. Once these pathways are identified, we will develop new tests and drugs that can be used to help diagnose and treat patients with chronic diseases of the gut, heart and kidney.
Department
Program
Team Grant: Health Challenges in Chronic Inflammation Initiative - (Full Appl)
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
296540
Name
Philpott Dana J
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Crohn's and Colitis Canada (Toronto, Ontario)
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Health Challenges in Chronic Inflammation Initiative - (Full Application)
Projecttitle
Nod-like receptors: linking innate immunity and inflammation to chronic disease
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$2,441,137
Cihrequipment2
$0
Programname2
Team Grant: Health Challenges in Chronic Inflammation Initiative - (Full Appl)
Keyworddelim
Biomarkers; Chronic Cardiovascular Disease; Chronic Kidney Disease; Inflammation; Inflammatory Bowel Disease; Innate Immunity; Nod-Like Receptors
Abstract
The Nod-like receptors (NLRs) are a family of genes that control the body's response to infection and injury. Since these genes control inflammation pathways in the body, if they are activated inappropriately, they can cause the development of a number of chronic diseases, including inflammatory bowel disease, cardiovascular and chronic kidney disease. Inappropriate NLR activation can also predispose people to chronic bacterial infections. Our team believes that the NLRs are important genes in inflammation and chronic disease and that efforts should be made to understand how they work and transfer that knowledge to help patients with common chronic conditions that involve the gut, heart and kidneys. Our goal with this project is to identify key pathways that are triggered by NLRs that control infection, inflammation, healing or chronic tissue damage. Once these pathways are identified, we will develop new tests and drugs that can be used to help diagnose and treat patients with chronic diseases of the gut, heart and kidney.
Competitiondate
201310
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Philpott, Dana J; Muruve, Daniel A
Approvedterm
5 ans 0 mois
Cihrcontribution2
Inst of Cancer Research~ $1,542,500~ $0~Inst of Infection & Immunity~ $381,001~ $0~Inst of Musculoskel Hlth &Arth~ $296,033~ $0~Inst of Nutr Metabolism &Diab~ $221,603~ $0~
