Grant: Operating Grant
McGill University
$841,225.00
Identification of PI-3K coupled signalling pathways involved in mammary tumour progression: Implication for resistance to targeted therapy.
FY 2013-14
Summary
The progression of a primary mammary epithelial cell to the malignant phenotype is thought to involve multiple genetic events including the activation of dominant acting oncogenes and the loss of specific tumour suppressor genes. The principle objective of this proposal is to elucidate the role of oncogene known as PI- 3K in mammary tumour progression. In the previous renewal we demonstrated that loss of PI-3K110aplha in the mammary epithelium impairs the ability of another oncogene known as ErbB2 to induce mammary tumours. However, after a period of time, ErbB2 mammary tumors that have become independent of PI-3K 110alpha arise. The principle objective of this proposal is to identify the molecular basis of this phenomenon. Given that resistance to drugs targeting PI-3K110alpha in breast cancer is an important clinical issue, identifying the resistance pathways is critical in developing better drugs for the treatment of breast cancer.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
291796
Name
Muller William J
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Progression & Therapeutics
Projecttitle
Identification of PI-3K coupled signalling pathways involved in mammary tumour progression: Implication for resistance to targeted therapy.
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$841,225
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Breast Cancer; Erbb2; Pi-3k; Transgenic Mouse Model
Abstract
The progression of a primary mammary epithelial cell to the malignant phenotype is thought to involve multiple genetic events including the activation of dominant acting oncogenes and the loss of specific tumour suppressor genes. The principle objective of this proposal is to elucidate the role of oncogene known as PI- 3K in mammary tumour progression. In the previous renewal we demonstrated that loss of PI-3K110aplha in the mammary epithelium impairs the ability of another oncogene known as ErbB2 to induce mammary tumours. However, after a period of time, ErbB2 mammary tumors that have become independent of PI-3K 110alpha arise. The principle objective of this proposal is to identify the molecular basis of this phenomenon. Given that resistance to drugs targeting PI-3K110alpha in breast cancer is an important clinical issue, identifying the resistance pathways is critical in developing better drugs for the treatment of breast cancer.
Competitiondate
201309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Muller, William J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $841,225~ $0~
