Grant: CIHR Fellowship
Ottawa Hospital Research Institute
$90,000.00
An in vivo screen to identify new mechanisms driving Natural Killer cell exhaustion in cancer
FY 2022-23
Summary
In addition to fighting infections, our immune system is also very well equipped to eliminate cancer cells. However, immune cells can get tired when they try to kill tumor cells for a prolonged time; something we call, quite literally, "exhaustion". When they are exhausted, immune cells lose their ability to effectively kill tumor cells or to interact with each other. Unfortunately, the molecular mechanisms that underlie the establishment of immune exhaustion are not clear, and it is therefore hard to therapeutically revert immune exhaustion. In this study, we developed an in vivo unbiased approach to discover new molecular targets that will help immune cells regain stamina, exit the exhausted state, and start killing cancer cells again. Discoveries from this project will help to design more effective cancer immunotherapies that will allow our immune system to better fight cancer.
Department
Program
CIHR Fellowship
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
472017
Name
Marotel Marie S
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
An in vivo screen to identify new mechanisms driving Natural Killer cell exhaustion in cancer
Programtype2
Fellowship Programs
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$90,000
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Cancer; Exhaustion; Immunology; Immunotherapies; Molecular Mechanisms; Natural Killer Cells; Screen; Tolerance; Transcriptional Regulation
Abstract
In addition to fighting infections, our immune system is also very well equipped to eliminate cancer cells. However, immune cells can get tired when they try to kill tumor cells for a prolonged time; something we call, quite literally, "exhaustion". When they are exhausted, immune cells lose their ability to effectively kill tumor cells or to interact with each other. Unfortunately, the molecular mechanisms that underlie the establishment of immune exhaustion are not clear, and it is therefore hard to therapeutically revert immune exhaustion. In this study, we developed an in vivo unbiased approach to discover new molecular targets that will help immune cells regain stamina, exit the exhausted state, and start killing cancer cells again. Discoveries from this project will help to design more effective cancer immunotherapies that will allow our immune system to better fight cancer.
Competitiondate
202210
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Marotel, Marie S
Approvedterm
2 ans 0 mois
Cihrcontribution2
~ $90,000~ $0~
