Grant: Project Grant

Viruses like reovirus are natural cell killers and immune stimulators, thus offering a unique approach to directly kill tumor cells and stimulate anti-tumor immunity. Our project will advance reovirus-based therapy of breast cancer by using combinations of innovations generated by our lab and others. We will also reveal important changes in the immune system that correspond with improved breast cancer outcomes, and identify limitations of reovirus therapy that need to be addressed by future advancements. Our project will also reveal the impact of host anti-reovirus antibodies on reovirus therapies and exploit novel reoviruses to overcome antibody-based inactivation of reovirus in tumors.