Grant: Master's Award: Canada Graduate Scholarships
Memorial University of Newfoundland
$17,500.00
The Consequences of Neonatal Methyl Group (Folate, Choline, and Betaine) Deficiency
FY 2011-12
Summary
A neonatal diet deficient in folate, choline, or betaine can have severe consequences on infant health. Folate, choline and betaine are methyl donors that are important for methionine and methyl metabolism in the body. When in excess, these methyl donors can spare the amount of methionine needed for methyl metabolism and increase the availability of methionine for protein synthesis, ultimately leading to an increase in growth. If these donors are deficient, methionine may be limited for normal protein synthesis and decrease the growth potential of an individual. The expression of genes involved in the onset of adult diseases, such as obesity, type 2 diabetes, and cardiovascular disease, have been linked to a methyl deficient diet early in infancy, which may have important metabolic consequences later in life.
Department
Program
Master's Award: Canada Graduate Scholarships
Recipient
Location
Newfoundland and Labrador, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
252474
Name
Furlong Kayla R
Region
Newfoundland and Labrador
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Canada Graduate Scholarships Master's Awards A
Projecttitle
The Consequences of Neonatal Methyl Group (Folate, Choline, and Betaine) Deficiency
Programtype2
Studentship Programs
Orgnameinp2
Memorial University of Newfoundland
Cihramount2
$17,500
Cihrequipment2
$0
Programname2
Master's Award: Canada Graduate Scholarships
Keyworddelim
Developmental Origins Hypothesis; Epigenetics (Dna Methylation); Methionine Cycle; Methionine Metabolism; Neonatal Metabolism; Neonatal Methionine Requirement; Neonatal Pig Model; Transmethylation
Abstract
A neonatal diet deficient in folate, choline, or betaine can have severe consequences on infant health. Folate, choline and betaine are methyl donors that are important for methionine and methyl metabolism in the body. When in excess, these methyl donors can spare the amount of methionine needed for methyl metabolism and increase the availability of methionine for protein synthesis, ultimately leading to an increase in growth. If these donors are deficient, methionine may be limited for normal protein synthesis and decrease the growth potential of an individual. The expression of genes involved in the onset of adult diseases, such as obesity, type 2 diabetes, and cardiovascular disease, have been linked to a methyl deficient diet early in infancy, which may have important metabolic consequences later in life.
Competitiondate
201202
Approvedterm2
1 yr 0 mth
Pinamesdelim
Furlong, Kayla R
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $17,500~ $0~
