Grant: Project Grant
University of Toronto
$1,139,850.00
Comprehensive analysis of RNA-binding proteins and their cellular function
FY 2018-19
Summary
RNA-binding proteins (RBPs) interact with "words" in RNA sequences. They do this by recognizing specific patterns of letters in RNA and/or shapes that RNA molecules adopt. These words are like instructions that control RNA fate or function (e.g. whether the messenger RNA is used to make protein). Because of their importance to numerous cellular processes, irregular RBP behaviour can lead to many different human diseases including cancer. To better understand what roles RBPs play in healthy and diseased cells, we propose to use experimental techniques developed in our labs to identify the RNA words recognized by more than a thousand human RBPs and five hundred RBPs from other organisms. We will use these data to develop an artificial intelligence system that can accurately predict RNA words that are recognized by RBPs. For some of the RBPs analyzed, we will also conduct additional experiments to further elucidate the roles that they play in cells.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
388505
Name
Morris Quaid D
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genomics: Systems and computational biology
Projecttitle
Comprehensive analysis of RNA-binding proteins and their cellular function
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$1,139,850
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Clip; Deep Learning; High-Throughput Sequencing; Machine Learning; Motifs; Post-Transcriptional Regulation; Rna Secondary Structure; Rna-Binding Domains; Rna-Binding Proteins; Rna-Binding Sequences
Abstract
RNA-binding proteins (RBPs) interact with "words" in RNA sequences. They do this by recognizing specific patterns of letters in RNA and/or shapes that RNA molecules adopt. These words are like instructions that control RNA fate or function (e.g. whether the messenger RNA is used to make protein). Because of their importance to numerous cellular processes, irregular RBP behaviour can lead to many different human diseases including cancer. To better understand what roles RBPs play in healthy and diseased cells, we propose to use experimental techniques developed in our labs to identify the RNA words recognized by more than a thousand human RBPs and five hundred RBPs from other organisms. We will use these data to develop an artificial intelligence system that can accurately predict RNA words that are recognized by RBPs. For some of the RBPs analyzed, we will also conduct additional experiments to further elucidate the roles that they play in cells.
Competitiondate
201809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Morris, Quaid D
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,139,850~ $0~
