Grant: Operating Grant
University of Alberta
$699,375.00
Regulation of nitric oxide and its effects: A pivotal point of control of mast cell phenotype and function.
FY 2008-09
Summary
Mast cells are involved in allergy and other inflammatory diseases. These cells store and rapidly secrete several powerful chemicals that cause the symptoms of allergic reactions. In recent years it has also been discovered that mast cells help defend us against bacterial and viral infections. Our goal is to understand how mast cell functions are controlled so that we will be able to prevent or inhibit the unwanted symptoms of allergy, but at the same time enhance the benefits that mast cells bring in our defence against infections.
We were one of the first research groups to discover that mast cells make nitric oxide, the gas that was the subject of the Nobel Prize in Medicine in 1998. Nitric oxide produced by mast cells inhibits their allergic reactions and appears to enhance their role in host defence. We are studying precisely how this works and the factors that control how and when mast cells make nitric oxide to regulate their functions. Our research is aimed at identification of new drugs or therapeutic targets for allergic and infectious diseases.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
172260
Name
Befus Dean
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
Regulation of nitric oxide and its effects: A pivotal point of control of mast cell phenotype and function.
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$699,375
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Aldolase A; Allergy; Asthma; B Bisphosphate; Bioenergetics; Epigenetics; Fructose 1; Inflammation; Influenza; Innate Immunity; Interferon Gamma; Mast Cells; Nitration; Nitric Oxide; Nitric Oxide Synthases; Post-Translational Modifications
Abstract
Mast cells are involved in allergy and other inflammatory diseases. These cells store and rapidly secrete several powerful chemicals that cause the symptoms of allergic reactions. In recent years it has also been discovered that mast cells help defend us against bacterial and viral infections. Our goal is to understand how mast cell functions are controlled so that we will be able to prevent or inhibit the unwanted symptoms of allergy, but at the same time enhance the benefits that mast cells bring in our defence against infections.
We were one of the first research groups to discover that mast cells make nitric oxide, the gas that was the subject of the Nobel Prize in Medicine in 1998. Nitric oxide produced by mast cells inhibits their allergic reactions and appears to enhance their role in host defence. We are studying precisely how this works and the factors that control how and when mast cells make nitric oxide to regulate their functions. Our research is aimed at identification of new drugs or therapeutic targets for allergic and infectious diseases.
Competitiondate
200809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Befus, Dean
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $699,375~ $0~
