Grant: Operating Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$983,939.00
Understanding virological and host determinants of HIV disease progression in a cohort of slow progressors
FY 2008-09
Summary
A certain number of patients, very few, infected with HIV are able to control the virus with no anti-HIV medication. This group of rare patients has been identified as «long term non-progressors» and may have special mechanisms that enables them to control the virus on their own. Learning more about such mechanisms may be very important to help designing vaccines and/or new therapies or prevention strategies for HIV. We will be recruiting HIV-1 infected subjects who are long term non-progressors and patients who have a normal disease progression, to study how various factors such as the type of virus they are infected with, their immune system, or their cells, help them to control the infection. In addition, we want to determine the long-term clinical and psychological natural history of the infection for such patients and evaluate whether superinfection may alter their disease progression.
Department
Program
Operating Grant
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
170855
Name
Tremblay Cécile L
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Clinical
Prcname2
Public, Community and Population Health - B
Projecttitle
Understanding virological and host determinants of HIV disease progression in a cohort of slow progressors
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$983,939
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Envelope; Hiv-1; Host Factors; Immune Escape; Long-Term Non Progressor; Long-Term Survivor; Nef; Recombination; Sequencing; Superinfection; Transmission; Viral Diversity; Viral Evolution
Abstract
A certain number of patients, very few, infected with HIV are able to control the virus with no anti-HIV medication. This group of rare patients has been identified as «long term non-progressors» and may have special mechanisms that enables them to control the virus on their own. Learning more about such mechanisms may be very important to help designing vaccines and/or new therapies or prevention strategies for HIV. We will be recruiting HIV-1 infected subjects who are long term non-progressors and patients who have a normal disease progression, to study how various factors such as the type of virus they are infected with, their immune system, or their cells, help them to control the infection. In addition, we want to determine the long-term clinical and psychological natural history of the infection for such patients and evaluate whether superinfection may alter their disease progression.
Competitiondate
200809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Tremblay, Cécile L; Bernard, Nicole F
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $983,939~ $0~
