Grant: Project Grant

Stress adaptation is exploited by cancer cells to survive and proliferate under adverse conditions, and thus the survival pathways induced by stress represent highly promising targets for the development of cancer therapies. Our work has uncovered a previously unknown pathway that is triggered when cells are exposed to stresses that include chemotherapeutics and the microenvironment at the core of solid tumours. This work is aimed at gaining a better understanding of the contribution of this pathway to stress adaption, which is necessary in order to exploit its potential as a target in the focused destruction of cancer cells.