Grant: Project Grant
Université de Sherbrooke
$1,235,475.00
The choroid plexus is the effector of omega-3 fatty acids to support the brain during aging.
FY 2024-25
Summary
The choroid plexus (ChP) is a secretory tissue located in the brain ventricles. It secretes a clear fluid called cerebrospinal fluid (CSF), which nourishes the brain and supports its functions. Our research has found that the composition of fats in the ChP membrane changes with aging, potentially altering its efficiency in producing essential proteins needed for optimal brain function. Additionally, we discovered that the ChP membrane composition can be modified by a diet rich in omega-3 fatty acids. Therefore, this study will investigate how dietary fats influence the functions of the ChP, with a focus on inflammation and the generation of new neurons in the aging brain. This project aims to provide evidence and a mechanistic explanation of how dietary omega-3 intake can modify brain cell functions and help maintain brain health during aging.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
507741
Name
Plourde Mélanie
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Nutrition, Food & Health
Projecttitle
The choroid plexus is the effector of omega-3 fatty acids to support the brain during aging.
Programtype2
Operating Grants
Orgnameinp2
Université de Sherbrooke
Cihramount2
$1,235,475
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Adeno-Associated Virus; Aging; Choroid Plexus; Inflammatory Mediators; Lipid Transporters; Lipidomics; Neurogenesis; Omega-3 Fatty Acids
Abstract
The choroid plexus (ChP) is a secretory tissue located in the brain ventricles. It secretes a clear fluid called cerebrospinal fluid (CSF), which nourishes the brain and supports its functions. Our research has found that the composition of fats in the ChP membrane changes with aging, potentially altering its efficiency in producing essential proteins needed for optimal brain function. Additionally, we discovered that the ChP membrane composition can be modified by a diet rich in omega-3 fatty acids. Therefore, this study will investigate how dietary fats influence the functions of the ChP, with a focus on inflammation and the generation of new neurons in the aging brain. This project aims to provide evidence and a mechanistic explanation of how dietary omega-3 intake can modify brain cell functions and help maintain brain health during aging.
Competitiondate
202409
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Plourde, Mélanie
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,235,475~ $0~
