Grant: Project Grant
Queen's University (Kingston, Ontario)
$765,000.00
Targeting TGF-beta signaling to achieve durable therapy responses in preclinical ovarian cancer models
FY 2019-20
Summary
Ovarian cancer is a leading cause of cancer-related deaths in Canadian women, and advances in ovarian cancer therapies are needed. Our project aims to improve the responses of ovarian cancers to both chemotherapy and mmunotherapy by inhibiting the signaling from an abundant factor in the ovarian tumour microenvironment. Our research uses advanced genetic and pharmacological tools to identify fundamental mechanisms of tumour biology, and
new combination therapies to improve therapy responses in ovarian cancer patients.
Department
Program
Project Grant
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
419226
Name
Craig Andrew W
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Biology & Therapeutics 2
Projecttitle
Targeting TGF-beta signaling to achieve durable therapy responses in preclinical ovarian cancer models
Programtype2
Operating Grants
Orgnameinp2
Queen's University (Kingston, Ontario)
Cihramount2
$765,000
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Chemoresistance; Combination Therapies; Immunotherapy; Metastasis; Ovarian Cancer; Syngeneic Tumour Models; Tgf Beta; Tumour Microenvironment
Abstract
Ovarian cancer is a leading cause of cancer-related deaths in Canadian women, and advances in ovarian cancer therapies are needed. Our project aims to improve the responses of ovarian cancers to both chemotherapy and mmunotherapy by inhibiting the signaling from an abundant factor in the ovarian tumour microenvironment. Our research uses advanced genetic and pharmacological tools to identify fundamental mechanisms of tumour biology, and
new combination therapies to improve therapy responses in ovarian cancer patients.
Competitiondate
202003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Craig, Andrew W
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $765,000~ $0~
