Grant: Operating Grant
Unity Health Toronto
$638,593.00
The role of the calcium-binding protein, S100B, in cardiovascular disease
FY 2010-11
Summary
A specific protein is found in heart and blood vessels in quantities that are altered in disease. These alterations contribute to changes in heart structure and function and may even be important for the development of the heart. This protein, S100B, acts both inside the cells of the heart and can be released from these cells to affect the function of neighbouring cells. In this project we will study the role of this unique protein in isolated heart cells and in genetically modified mice (as models of human heart disease by creating heart attacks, high blood pressure, and diabetes in these animals). The role of S100B in the heart makes it a very attractive target for the development of new treatments for numerous diseases including heart attacks, heart failure, high blood pressure, hardening of the arteries, and the consequences of diabetes.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
210653
Name
Parker Thomas G
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Cardiovascular System - B: Heart and Circulation
Projecttitle
The role of the calcium-binding protein, S100B, in cardiovascular disease
Programtype2
Operating Grants
Orgnameinp2
Unity Health Toronto
Cihramount2
$638,593
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Calcium-Binding Proteins; Myocardial Infarction; Transgenic Mice
Abstract
A specific protein is found in heart and blood vessels in quantities that are altered in disease. These alterations contribute to changes in heart structure and function and may even be important for the development of the heart. This protein, S100B, acts both inside the cells of the heart and can be released from these cells to affect the function of neighbouring cells. In this project we will study the role of this unique protein in isolated heart cells and in genetically modified mice (as models of human heart disease by creating heart attacks, high blood pressure, and diabetes in these animals). The role of S100B in the heart makes it a very attractive target for the development of new treatments for numerous diseases including heart attacks, heart failure, high blood pressure, hardening of the arteries, and the consequences of diabetes.
Competitiondate
201009
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Parker, Thomas G
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $638,593~ $0~
