Grant: Project Grant
McGill University
$990,675.00
A precision medicine approach for treatment of low bone mass in Klinefelter Syndrome
FY 2025-26
Summary
There is a need for developing treatments to stimulate bone formation in regenerative medicine since the approved treatments are cumbersome for the patients and have potential high-risk side effects. Using a target that was cloned in our laboratory and a high-throughput screen of chemical libraries, we have identified a lead compound (small molecule) that stimulates bone formation. We will further characterize the compound for its ability to increase bone mass and strength in preclinical models of the low bone mass disease Klinefelter syndrome and attempt to synthesize analogs with improved potency and characteristics.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
532229
Name
St-Arnaud René
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage
Projecttitle
A precision medicine approach for treatment of low bone mass in Klinefelter Syndrome
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$990,675
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Bone; Cell Differentiation; Drug Development; Klinefelter Syndrome; Medicinal Chemistry; Metabolic Bone Disease; Osteoblasts; Preclinical Testing
Abstract
There is a need for developing treatments to stimulate bone formation in regenerative medicine since the approved treatments are cumbersome for the patients and have potential high-risk side effects. Using a target that was cloned in our laboratory and a high-throughput screen of chemical libraries, we have identified a lead compound (small molecule) that stimulates bone formation. We will further characterize the compound for its ability to increase bone mass and strength in preclinical models of the low bone mass disease Klinefelter syndrome and attempt to synthesize analogs with improved potency and characteristics.
Competitiondate
202509
Approvedterm2
5 yrs 0 mth
Pinamesdelim
St-Arnaud, René
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $990,675~ $0~
