Grant: Project Grant
Research Institute of the McGill University Health Centre
$726,750.00
Understanding the basis of diaphragmatic weakness in critical illness
FY 2019-20
Summary
Patients admitted to the intensive care unit (ICU) often develop a severe loss of muscularity and muscle weakness, which can also involve the main breathing muscle (the diaphragm). This causes difficulties in removing patients from artificial breathing machines and also leads to prolonged muscle weakness once patients leave the ICU. The purpose of this project is to develop a better understanding of the biological mechanisms behind this problem, so that more effective treatments and preventive measures can be developed.
Department
Program
Project Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
407809
Name
Petrof Basil J
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Respiratory System
Projecttitle
Understanding the basis of diaphragmatic weakness in critical illness
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$726,750
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Critical Illness Myopathy; Cytokines; Diaphragm Function; Mechanical Ventilation; Mitochondria; Muscle Atrophy; Muscle Injury; Muscle Physiology; Muscle Regeneration; Sepsis
Abstract
Patients admitted to the intensive care unit (ICU) often develop a severe loss of muscularity and muscle weakness, which can also involve the main breathing muscle (the diaphragm). This causes difficulties in removing patients from artificial breathing machines and also leads to prolonged muscle weakness once patients leave the ICU. The purpose of this project is to develop a better understanding of the biological mechanisms behind this problem, so that more effective treatments and preventive measures can be developed.
Competitiondate
201909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Petrof, Basil J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $726,750~ $0~
