Grant: Project Grant
University of Toronto
$933,300.00
Novel Mechanisms of Subversion of Host Processes by Epstein-Barr Virus Proteins
FY 2021-22
Summary
Epstein-Barr virus (EBV) infects most people worldwide, persists for a life-time and is a causative agent in several types of lymphoma, gastric carcinoma and nasopharyngeal carcinoma, accounting for 200,000 cancer cases per year. In addition, accumulating evidence has identified EBV infection as an important factor in the development of multiple sclerosis. Successful infection by EBV involves the expression of ~80 protein viral proteins, many of which have poorly characterized functions. Many of these proteins are known or presumed to manipulated cellular processes to enable viral infection. We have been using proteomics approaches to define the host targets of EBV proteins and, in doing so, have discovered new cellular pathways and cellular proteins that are manipulated by EBV. This project will determine the mechanisms of these cellular manipulations and their importance for EBV infection. This information will enable new approaches to inhibit EBV infection, thereby limiting the development of EBV-associated cancers and multiple sclerosis.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
462017
Name
Frappier Lori D
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Novel Mechanisms of Subversion of Host Processes by Epstein-Barr Virus Proteins
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$933,300
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Apobec3b; Gigyf2; Mirna; Protein-Protein Interactions; Proteomics; Risc; Rna-Seq
Abstract
Epstein-Barr virus (EBV) infects most people worldwide, persists for a life-time and is a causative agent in several types of lymphoma, gastric carcinoma and nasopharyngeal carcinoma, accounting for 200,000 cancer cases per year. In addition, accumulating evidence has identified EBV infection as an important factor in the development of multiple sclerosis. Successful infection by EBV involves the expression of ~80 protein viral proteins, many of which have poorly characterized functions. Many of these proteins are known or presumed to manipulated cellular processes to enable viral infection. We have been using proteomics approaches to define the host targets of EBV proteins and, in doing so, have discovered new cellular pathways and cellular proteins that are manipulated by EBV. This project will determine the mechanisms of these cellular manipulations and their importance for EBV infection. This information will enable new approaches to inhibit EBV infection, thereby limiting the development of EBV-associated cancers and multiple sclerosis.
Competitiondate
202203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Frappier, Lori D
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $933,300~ $0~
