Grant: Operating Grant
University of Calgary
$841,563.00
Regulation of neuroinflammation and neuropathology in multiple sclerosis by the matrix metalloproteinase inducer, EMMPRIN
FY 2008-09
Summary
Many factors contribute to the progression of multiple sclerosis (MS) including the expression of a family of proteins called matrix metalloproteinases (MMPs). Many MMPs are upregulated in MS lesions and it would be advantageous to switch these off. Dr. Yong will investigate an inducer of the expression of many MMPs, referred to as EMMPRIN. The research will focus on the expression of EMMPRIN in MS brain lesions, then address how EMMPRIN regulates the pathology of MS, and will further use an animal model of MS in order to examine whether inhibiting EMMPRIN would resolve the disease. Besides an understanding of the evolution of the MS disease process, this application may provide new insights into a potential new treatment of MS.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
171064
Name
Yong Voon W
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Cell Biology & Mechanisms of Disease
Projecttitle
Regulation of neuroinflammation and neuropathology in multiple sclerosis by the matrix metalloproteinase inducer, EMMPRIN
Programtype2
Operating Grants
Orgnameinp2
University of Calgary
Cihramount2
$841,563
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Experimental Autoimmune Encephalomyelitis; Matrix Metalloproteinases; Multiple Sclerosis; Neuroinflammation; Neuropathology; Recovery
Abstract
Many factors contribute to the progression of multiple sclerosis (MS) including the expression of a family of proteins called matrix metalloproteinases (MMPs). Many MMPs are upregulated in MS lesions and it would be advantageous to switch these off. Dr. Yong will investigate an inducer of the expression of many MMPs, referred to as EMMPRIN. The research will focus on the expression of EMMPRIN in MS brain lesions, then address how EMMPRIN regulates the pathology of MS, and will further use an animal model of MS in order to examine whether inhibiting EMMPRIN would resolve the disease. Besides an understanding of the evolution of the MS disease process, this application may provide new insights into a potential new treatment of MS.
Competitiondate
200809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Yong, Voon W
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $841,563~ $0~
