Grant: Operating Grant
Unity Health Toronto
$472,514.00
The Role of Sirtuin1 in Diabetic Nephropathy: Experimental and Clinical Studies
FY 2011-12
Summary
Many of the complications of diabetes, such as kidney and heart disease, are similar to those of ageing, but occurring at a much earlier age. In other words, diabetes seems to accelerate the ageing process. Recent research in to the mechanisms that contribute to ageing has identified a pivotal role for a chemical that is present in all cells called Sirtuin-1, or Sirt1. The more Sirt1 a cell or organism has, the longer it lives. In our preliminary studies we have shown that Sirt1 levels are dramatically reduced in kidney tissue from individuals with diabetes. We have further shown that a drug which activates Sirt1, can lessen the extent of kidney damage in a mouse model of diabetic kidney disease. Given these exciting observations, we now seek to perform more definitive studies in animals with the ultimate goal of providing a new potential treatment for the prevention of kidney disease in diabetes.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
240066
Name
Gilbert Richard E
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Hematology, Digestive Disease & Kidney
Projecttitle
The Role of Sirtuin1 in Diabetic Nephropathy: Experimental and Clinical Studies
Programtype2
Operating Grants
Orgnameinp2
Unity Health Toronto
Cihramount2
$472,514
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Diabetes; Humans; Kidney Disease; Mice
Abstract
Many of the complications of diabetes, such as kidney and heart disease, are similar to those of ageing, but occurring at a much earlier age. In other words, diabetes seems to accelerate the ageing process. Recent research in to the mechanisms that contribute to ageing has identified a pivotal role for a chemical that is present in all cells called Sirtuin-1, or Sirt1. The more Sirt1 a cell or organism has, the longer it lives. In our preliminary studies we have shown that Sirt1 levels are dramatically reduced in kidney tissue from individuals with diabetes. We have further shown that a drug which activates Sirt1, can lessen the extent of kidney damage in a mouse model of diabetic kidney disease. Given these exciting observations, we now seek to perform more definitive studies in animals with the ultimate goal of providing a new potential treatment for the prevention of kidney disease in diabetes.
Competitiondate
201109
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Gilbert, Richard E
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $472,514~ $0~
