Grant: CEEHRC Epigenomics Platform - Epigenomic Mapping Centres (EMC)

Ten years after completion of the Human Genome Project providing us the first full sequence of bases in our genome the research community is now joining forces for its next challenge: epigenome mapping. This global effort is necessary to answer how does the genome deploy hundreds of different programs leading to different fates in cell development, altered cell function and sometimes in disease even when the genome sequence remains unchanged. By systematic mapping of variable modifications in DNA-bases such as methylation, differential packing of DNA around proteins (histones) and resulting changes in gene expression one can gain insight how epigenetic modifications in genome govern its function. To join global efforts (The International Human Epigenome Consortium) we will establish an Epigenome Mapping Centre (EMC) at McGill University that builds upon a high-throughput sequencing infrastructure with a critical mass of expertise and technology available to contribute significantly in deciphering the functional code of the human genome. Our work is internationally coordinated and will support research initiatives across the Canadian research community. We draw upon our previous experience in studying human genome function and molecular mechanisms involved in disease coupled with our expertise in advanced technologies applicable for epigenomics. We apply epigenome mapping to understand interactions between environment and genome in human blood cells, to interpret diseases impacting metabolism using tissue samples and to study how epigenetic changes can alter function of the brain. EMC McGill is a national hub housing a critical mass of epigenomics expertise supported by state-of-the-art genomics infrastructure. The integrated operation contributes to Canadian leadership in epigenome research, the next frontier in biomedicine.