Grant: Randomized Controlled Trials

The aim of this study is to test the feasability of a multi center trial on the effects of glutamine on mortality and infectious morbidity in adult burn patient. This will include recruitment rate, compliance with institutionnal and protocol regulations, and compliance with study intervention and data collection. Glutamine has been shown to decrease infections in patients treated in intensive care settings or after surgery. In burn patient, 2 small studies have shown decreased blood infection with glutamine administration and in one study mortality was much lower in patients with glutamine than in patients with placebo. This unexpected finding prompted us to propose a multi center study with a large number of patients. Since a trial of this mmagnitude has never been conducted we propose to conduct a feasability study that will include a fraction of the patient population recruted by a fraction of the participating centers. All clinical outcome will be measured and the study patients will be included in the final analysis, should the complete study be conducted.