Grant: Operating Grant-PA: INMD Start Up Funds (bridge funding) - Clinician Scientists
Institut de recherches cliniques de Montréal
$100,000.00
ApoB-lipoproteins, adipose tissue NLRP3 inflammasome and insulin resistance
FY 2011-12
Summary
In this project we will investigate the role of the particles that carry lipids in the blood in the promotion of immunity pathways leading to fat tissue dysfunction and other risks for type 2 diabetes in humans. We will also investigate the role of omega-3 fatty acids, which are the type of fat found in fish oil, in the improvement of these metabolic risk factors in human. To do so, we will enroll about 80 overweight and obese men and women in a 12-weeks dietary intervention using omega-3 fatty acid supplementation. The risks for type 2 diabetes will be examined before and after the intervention in the body as a whole and in a fat tissue biopsies.
Department
Program
Operating Grant-PA: INMD Start Up Funds (bridge funding) - Clinician Scientists
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
247148
Name
Faraj May
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Clinical
Prcname2
Nutrition, Food & Health
Projecttitle
ApoB-lipoproteins, adipose tissue NLRP3 inflammasome and insulin resistance
Programtype2
Operating Grants
Orgnameinp2
Institut de recherches cliniques de Montréal
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Operating Grant-PA: INMD Start Up Funds (bridge funding) - Clinician Scientists
Keyworddelim
12 Weeks Omega-3 Fatty Acids-Rich Diet; In Vivo And And Ex Vivo Human And Mice Models; Innate Immunity And Nlrp3 Inflammasome; Insulin Sensitivity And Secretion; Lipids And Apob-Lipoproteins; Overweight And Obese Subjects; Postprandial Fat Clearance; Stable And Radioactive Isotope Tracing; White Adipose Tissue Function
Abstract
In this project we will investigate the role of the particles that carry lipids in the blood in the promotion of immunity pathways leading to fat tissue dysfunction and other risks for type 2 diabetes in humans. We will also investigate the role of omega-3 fatty acids, which are the type of fat found in fish oil, in the improvement of these metabolic risk factors in human. To do so, we will enroll about 80 overweight and obese men and women in a 12-weeks dietary intervention using omega-3 fatty acid supplementation. The risks for type 2 diabetes will be examined before and after the intervention in the body as a whole and in a fat tissue biopsies.
Competitiondate
201109
Approvedterm2
1 yr 0 mth
Pinamesdelim
Faraj, May
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
